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AI in MedicineAugust 17, 2026Source: Journal of Medical Internet Research

Therapeutic interaction features of AI chatbots in depression: systematic review and meta-analysis

A systematic review in a leading eHealth journal examined the clinical effectiveness of AI-driven chatbots for depression and how their interaction features relate to outcomes and adherence. The meta-analysis found that chatbots tended to reduce depressive symptoms compared with control conditions, but after applying more conservative statistical methods, the effect was no longer statistically significant, underscoring heterogeneous evidence and the need for more rigorous trials.

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